Questões de Inglês - Grammar

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Does a C-section affect the baby’s immune system?

The natural birth process can be messy, stressful, and long remembered by both moms and dads. However, there is an unexplained link between decreasing rates of vaginal delivery and increasing rates of chronic inflammatory and metabolic disease in children growing up in today’s world.

Nowadays, 20% of Cesarean sections performed worldwide have no medical justification. Although often preferred by both patients and obstetricians, Cesarean sections are not risk-free and might have a hidden impact on the baby immune system.

During the natural birth process, the baby is exposed to microorganisms from the mother. This normal exposure process has been connected to healthy gut microbiome growth, further affecting baby immune system development. Nevertheless, it is unclear whether disruption of the exposure process occurring during cesarean section affects gut microbiome formation in neonates.

A recent study published in Nature Communications determined whether the mode of delivery does affect the baby immune system. The researchers examined stool samples taken one to five days after the birth of 33 babies born by either vaginal or cesarean deliveries. They performed an analysis of the genetic material from uncultured microorganisms found in these samples. This method allows the detection of numerous bacterial strains and the evaluation of any differences in bacterial classification among samples.

The study found differences in the microbiome of babies born naturally or by a Cesarean section. Stool samples of babies delivered by Cesarean section lacked the bacteria present in samples taken from naturally born babies. In addition, the researchers extracted an immune stimulating factor called lipopolysaccharide (LPS) from the samples. This bacteria-derived substance is known to cause chronic inflammatory disease and metabolic disease in children and adults.

They used extracted LPS to stimulate cultured immune cells and quantifies the expression of several inflammationcausing factors. Interestingly, the study discovered that LPS isolated from stool samples of naturally born babies stimulates higher levels of inflammation-related substances secretion. On the other hand, LPS isolated from stool samples of babies delivered by Cesarean section had lower inflammatory effects.

The results suggest that Cesarean section procedures divert the process of gut microbiome development to alternative pathways. This alteration might underlie the increase in the prevalence of chronic inflammatory and metabolic diseases in developed countries.

It seems that the mode of delivery might have lifelong influences on a newborn’s health.

Adaptado de: https://medicalnewsbulletin.com/c-section-babyimmune-system/ Acessado em 02 de março de 2020.

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Widespread testing begins on malaria vaccine

Mothers wait for their children to be vaccinated against malaria at the start of a pilot program at Mitundu Community Hospital, in Lilongwe, Malawi, on April 23, 2019.

    With malaria deaths rebounding worldwide, a pilot program testing a new and fiercely debated malaria vaccine began on Tuesday in Malawi. Dr. Katherine O’Brien, the World Health Organization’s director of immunization, called the rollout “a historic moment in the fight against malaria,” and said the testing will soon expand to malarious regions of Ghana and Kenya. But the vaccine, known as RTS,S, or Mosquirix, has been in development for more than 30 years, and it has serious drawbacks that have led some experts to argue that it does not work well enough to spend millions of dollars pursuing.

    Malaria kills about 450,000 people a year, most of them young African children. Over the last 15 years, the death rate has been reduced by more than half through extensive, donor-funded efforts to hand out free mosquito nets, spray homes with insecticide and treat people with a new generation of medicines. Nevertheless, deaths have increased again as money has run short, populations have grown, resistance to some new drugs has emerged and mosquitoes have expanded their ranges. Finding new weapons is crucial, experts agree, but making a malaria vaccine has proved challenging in the extreme.

    The new vaccine has many weaknesses. It is inconvenient: a child must receive four injections before age 2, sometimes at intervals that do not match the routine vaccine schedules for most other diseases. And it is only partly effective. Testing in more than 10,000 African children from 2009 to 2014 showed that, even after four doses, the vaccine prevented only about 40 percent of detectable malaria infections. The vaccine reduced the occurrence of severe malaria by about 30 percent. It did not protect well against parasite strains that were poor genetic matches, raising a concern that, over time, parasites could evolve resistance to the vaccine as they have to drugs.

(Donald G. McNeil Jr. www.nytimes.com, 24.04.2019. Adaptado.)

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    Because it is locked away inside the skull, the brain is hard to study. Looking at it requires finicky machines which use magnetism or electricity or both to bypass the bone. There is just one tendril of brain tissue that can be seen from outside the body without any mucking about of this sort. That is the retina. Look into someone’s eyes and you are, in some small way, looking at their brain.

    This being so, a group of researchers decided to study the structure of the eye for signs of cognitive decline. Changes in the brain, they reasoned, might lead to changes in the nervous tissue connected to it. They focused on a part of the eye called the retinal nerve-fibre layer (RNFL). This is the lowest layer of the retina and serves to link the light-sensitive tissue above to the synapses which lead to the brain. The team’s results show that people with a thin RNFL are more likely to fail cognitive tests than those with a thick one. They are also more likely to suffer cognitive decline as they age.

(www.economist.com, 30.06.2018. Adaptado.)

Read the text below and answer the following question based on it.

Does a C-section affect the baby’s immune system?

The natural birth process can be messy, stressful, and long remembered by both moms and dads. However, there is an unexplained link between decreasing rates of vaginal delivery and increasing rates of chronic inflammatory and metabolic disease in children growing up in today’s world.

Nowadays, 20% of Cesarean sections performed worldwide have no medical justification. Although often preferred by both patients and obstetricians, Cesarean sections are not risk-free and might have a hidden impact on the baby immune system.

During the natural birth process, the baby is exposed to microorganisms from the mother. This normal exposure process has been connected to healthy gut microbiome growth, further affecting baby immune system development. Nevertheless, it is unclear whether disruption of the exposure process occurring during cesarean section affects gut microbiome formation in neonates.

A recent study published in Nature Communications determined whether the mode of delivery does affect the baby immune system. The researchers examined stool samples taken one to five days after the birth of 33 babies born by either vaginal or cesarean deliveries. They performed an analysis of the genetic material from uncultured microorganisms found in these samples. This method allows the detection of numerous bacterial strains and the evaluation of any differences in bacterial classification among samples.

The study found differences in the microbiome of babies born naturally or by a Cesarean section. Stool samples of babies delivered by Cesarean section lacked the bacteria present in samples taken from naturally born babies. In addition, the researchers extracted an immune stimulating factor called lipopolysaccharide (LPS) from the samples. This bacteria-derived substance is known to cause chronic inflammatory disease and metabolic disease in children and adults.

They used extracted LPS to stimulate cultured immune cells and quantifies the expression of several inflammationcausing factors. Interestingly, the study discovered that LPS isolated from stool samples of naturally born babies stimulates higher levels of inflammation-related substances secretion. On the other hand, LPS isolated from stool samples of babies delivered by Cesarean section had lower inflammatory effects.

The results suggest that Cesarean section procedures divert the process of gut microbiome development to alternative pathways. This alteration might underlie the increase in the prevalence of chronic inflammatory and metabolic diseases in developed countries.

It seems that the mode of delivery might have lifelong influences on a newborn’s health.

Adaptado de: https://medicalnewsbulletin.com/c-section-babyimmune-system/ Acessado em 02 de março de 2020.

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Air Traffic Controllers

  Air traffic controllers coordinate the movement of air
traffic, to ensure that aircraft stay safe distances apart.
  Duties
  Air traffic controllers typically do the following:
[5]  - Issue landing and takeoff instructions to pilots;
  - Monitor and direct the movement of aircraft on the
ground and in the air, using radar, computers, or visual
references;
  - Control all ground traffic at airports, including baggage
[10] vehicles and airport workers;
  - Manage communications by transferring control of
departing flights to traffic control centers and accepting
control of arriving flights;
  - Provide information to pilots, such as weather updates,
[15] runway closures, and other critical information; and
  - Alert airport response staff, in the event of an aircraft
emergency.
  Air traffic controllers' primary concern is safety, but they
also must direct aircraft efficiently to minimize delays. They
[20] manage the flow of aircraft into and out of the airport
airspace, guide pilots during takeoff and landing, and monitor
aircraft, as they travel through the skies.
  Controllers usually manage multiple aircraft at the same
time and must make quick decisions to ensure the safety of
[25] the aircraft. For example, a controller might direct one
aircraft on its landing approach, while providing another
aircraft with weather information.
Adapted from: ttps://collegegrad.com/careers/air-traffic-controllers